Progeneca provides quality services in the following areas: - Gene
cloning
- Choice of expression vector
- Expression system selection
- Selection of best expressing clones
- Creation of research cell bank
- Master cell bank generation
- Protein purification method development
- Establishing protein purity criteria
- Transfer of method to CRO for
pilot scale production
- Translating the Pilot scale process into manufacturing
- Pilot and Manufacturing stage monitoring to make sure that quality is not compromised
- Protein stability testing.
- Filing of Pre-IND and IND
- Site-specific PEGylation of protein drugs. PEGylation helps the protein drug to escape immune system of the patient and thereby prolongs the life span of the protein drug in the body.
- Protein sequencing by LC-MS/MS
- Site-specific mutagenesis and other techniques to stabilize the protein
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